Intracellular Ca2+ activates phospholipase C
نویسندگان
چکیده
منابع مشابه
Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells.
It is recognized in many cellular systems that the receptor/G-protein activation of phospholipase C and Ins(1,4,5)P3 production is the transduction pathway regulating the release of Ca2+ from internal stores. Ca2+ signals can now be monitored at the level of single cells but the biochemical detection of Ins(1,4,5)P3 cannot match this resolution. It is often difficult or impossible to directly a...
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ates rapid Ca store release through the activation of InsP3 receptors (IP3R) in the endoplasmic reticulum (ER) membrane (Berridge et al., 2000). Following this initial Randen L. Patterson,1,6 Damian B. van Rossum,2,6 Diana L. Ford,2 Kenneth J. Hurt,1 Sun Sik Bae,3 Pann-Ghill Suh,3 Tomohiro Kurosaki,4 Ca store-release, external Ca enters through plasma Solomon H. Snyder,1,5 and Donald L. Gill2 m...
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Calcium signaling within astrocytes in the CNS may play a role comparable to that of electrical signaling within neurons. ATP is a molecule known to produce Ca2+ responses in astrocytes, and has been implicated as a mediator of intercellular Ca2+ signaling in other types of nonexcitable cells. We characterized the signal transduction pathway for ATP-evoked Ca2+ responses in cultured astrocytes ...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 1988
ISSN: 0166-2236
DOI: 10.1016/0166-2236(88)90174-9